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Louis Aronne, a principal investigator on the clinical trial involving Zepbound and Wegovy, told ABC News that the success of drugs using tirzepatide is likely because the ingredient targets two hormones instead of one
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Introduction How GLP-1 signaling supports brain health Counteracting amyloid, tau, and neuroinflammation Neuroprotective effects in experimental models Early clinical trials show encouraging, but mixed results Evidence from cardiovascular outcome trials and real-world studies Limitations and challenges Looking ahead: Ongoing trials and future opportunities References Further reading From reduced amyloid and neuroinflammation in experimental models to mixed cognitive outcomes in clinical trials, emerging evidence is testing whether GLP-1 receptor agonists can move beyond metabolic therapy to become meaningful treatments for Alzheimer’s disease
